Clinical use of calcium channel antagonist drugs by lionel h opie md phd frcp professor of medicine university of cape town cape town south africa. Calcium channel blocking agents restrict the amount of calcium entering cardiac and smooth muscle cells by blocking voltage gated calcium channels this causes blood vessels to relax and widen vasodilate improves oxygen supply to the heart and lowers blood pressure some calcium channel blockers . Clinical indications for calcium channel blockers somani p mayhew he ca2 channel blocking agents have proven to be one of the most exciting groups of drugs for management of many cardiovascular diseases and as potentially first line agents for treatment of angina pectoris and hypertension. Calcium channel blockers prevent calcium from entering cells of the heart and blood vessel walls resulting in lower blood pressure calcium channel blockers also called calcium antagonists relax and widen blood vessels by affecting the muscle cells in the arterial walls some calcium channel . Calcium channel blockers ccb calcium channel antagonists or calcium antagonists are several medications that disrupt the movement of calcium ca 2 through calcium channels 3 calcium channel blockers are used as antihypertensive drugs ie as medications to decrease blood pressure in patients with hypertension
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