Note citations are based on reference standards however formatting rules can vary widely between applications and fields of interest or study the specific requirements or preferences of your reviewing publisher classroom teacher institution or organization should be applied. Editors note please see the accompanying expert analysis response to the 2017 hypertension guidelines approaches to mild hypertension and combination therapy the 2017 acc aha guideline for the prevention detection evaluation and management of high blood pressure in adults is a landmark achievement. The therapeutics initiative presents critically appraised summary evidence primarily from controlled drug trials such evidence applies to patients similar to those involved in the trails and may not be generalizable to every patient. Furberg cd cutler ja probstfield jl et al the systolic hypertension in the elderly program mild hypertension from drug trials to practice raven press new york 59 63 1987 rationale and design of a randomized clinical trial on prevention of stroke in isolated systolic hypertension. Another potential justification for placebo use in pediatric antihypertensive trials is that many children with mild to moderate uncomplicated hypertension receive nonpharmacological treatment before starting drug therapy 26 this practice is based on numerous studies that have demonstrated significant blood pressure reduction in hypertensive
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