The newer dihydropyridine calcium antagonists are structurally related to nifedipine but may provide greater vascular selectivity and wider clinical utility five new dihydropyridines nisoldipine. Second generation agents include isradipine nicardipine and felodipine amlodipine is considered a third generation dihydropyridine calcium channel antagonists block the inward movement of calcium by binding to the l type calcium channels in the heart and in smooth muscle of the peripheral vasculature calcium channel blockers act as . New generation calcium channel blockers in hypertensive treatment among antihypertensive drugs calcium channel blockers which inhibit l type voltage gated calcium channels are potent vasodilators and have been used as a first or second line drug dihydropyridine class calcium channel blockers are categorized into three . Calcium channel blockers ccb calcium channel antagonists or calcium antagonists are several medications that disrupt the movement of calcium ca 2 this was the first known use of a calcium channel blocker drug which were not in wide use in the western world until the 1960s see also ace inhibitor angiotensin ii receptor antagonist. Second generation of calcium antagonists h1 antagonist wikipedia h 1 antagonists also called h 1 blockers are a class of medications that block the action of histamine at the h 1 receptor helping to relieve
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