Second generation dihydropyridine calcium antagonists greater vascular selectivity and some unique applications bayhan m watson a the effects of a calcium antagonist nimodipine upon physiological responses of the cerebral vasculature and its possible influence upon focal cerebral ischaemia mehta jl improvement in exercise . 1 the second generation of calcium antagonists what are they 2 the chemistry of the second generation calcium antagonists 3 the molecular biology of the voltage dependent calcium antagonist sensitive calcium channels 4 calcium antagonists and the calcium release channels of the sarcoplasmic reticulum 5 up and down regulation of . Second generation agents include isradipine nicardipine and felodipine amlodipine is considered a third generation dihydropyridine calcium channel antagonists block the inward movement of calcium by binding to the l type calcium channels in the heart and in smooth muscle of the peripheral vasculature calcium channel blockers act as . New generation calcium channel blockers in hypertensive treatment among antihypertensive drugs calcium channel blockers which inhibit l type voltage gated calcium channels are potent vasodilators and have been used as a first or second line drug dihydropyridine class calcium channel blockers are categorized into three . efficacy of second generation calcium antagonists in the management of acute cerebral ischaemia 179 clinical data 182 mode of action 182 subarachnoid haemorrhage 183 effect of second generation calcium antagonists on recovery after subarachnoid haemorrhage 184 summary 184 chapter 15 second generation calcium antagonists
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