Thrombolytic medicines are approved for the emergency treatment of stroke and heart attackthe most commonly used drug for thrombolytic therapy is tissue plasminogen activator tpa but other drugs can do the same thing. Tissue plasminogen activator abbreviated tpa or plat is a protein involved in the breakdown of blood clots it is a serine protease ec 342168 found on endothelial cells the cells that line the blood vessels . Clinical practice guidelines published by both the american heart association and american stroke association aha asa in 2007 and the american college of chest physicians in 2008 recommend the use of the thrombolytic agent recombinant tissue plasminogen activator rtpa for the treatment of acute ischemic stroke ais in eligible patients 1 2. Since intracerebral hemorrhage was a frequent major complication reported in early trials of thrombolytic therapy 45 the use of recombinant human tissue plasminogen activator t pa for cerebral . 9 hacke w kaste m fieschi c toni d lesaffre e von kummer h boysen g bluhmki e hoxter g mahegre me hennerici m intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke the european cooperative acute stroke study ecass
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